מכאן שהרפואה המשולבת, זו המנסה לעשות שימוש בשני העולמות, הקונבנציונלי והאלטרנטיבי, מתמקדת באדם לא פחות מאשר במחלה. ...
מתוך הערך: המדריך לטיפול בסוכרת

הטיפול התרופתי בכאב בחולה המורכב - נייר עמדה

מתוך ויקירפואה

ערך זה נמצא בבדיקה ועריכה על ידי מערכת ויקירפואה,
וייתכן כי הוא לא ערוך ומוגה.


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ערך זה הוא נייר עמדה סגור לעריכה
אמנות הטיפול התרופתי בכאב בחולה המורכב
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האיגוד המפרסם איגודים משתתפים
תאריך פרסום פברואר 2018
יוצר הערך פרופ׳ אהוד גרוסמן; פרופ׳ עדי לייבה; ד"ר ברוך יצחק; ד"ר זאזא יעקבישוילי; פרופ׳ רם דיקמן; ד"ר לי גולדשטיין
ניירות עמדה מתפרסמים ככלי עזר לרופא/ה ואינם באים במקום שיקול דעתו/ה בכל מצב נתון.

כל הכתוב בלשון זכר מתייחס לשני המגדרים.
 

לערכים נוספים הקשורים לנושא זה, ראו את דף הפירושיםכאב

ישנן תרופות נוספות במאגר התרופות של משרד הבריאות שאינן מופיעות ברשימה זו.

Pain Treatment + Hypertension

מקרא
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Pain Treatment + Kidney

מקרא
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Pain Treatment + Diabetes

מקרא
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מעודכן


מקורי


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Pain Treatment + Coronary / CHF

מקרא
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Pain Treatment + Peptic Ulcer Disease

מקרא
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Pain Treatment + Cirrhosis

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Pharmacologic Pain Treatment In High Risk Patients

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איגודים משתתפים

יוצרי הערך

  • Pain Treatment + Hypertension (HTN) - פרופ׳ אהוד גרוסמן
  • Pain Treatment + Kidney - פרופ׳ עדי לייבה
  • Pain Treatment + Diabetes - ד"ר ברוך יצחק
  • Pain Treatment + Coronary & CHF - ד"ר זאזא יעקבישוילי
  • (Pain Treatment + Peptic Ulcer Disease (PUD - פרופ׳ רם דיקמן
  • Pain Treatment + Cirrhosis - ד"ר לי גולדשטיין

ביבליוגרפיה

Pain Treatment + Hypertension

  1. Grossman A, Messerli FH, Grossman E. Drug induced nypertenslon - An unappreciated cause of secondary nypertension. Eur J Pharmacol. 2015;763:15-22. Day RO et al. BMJ 2013; f3195.
  2. Sudano I, et al. Acetaminophen increases blood pressure in patients with coronary artery disease. Circulation. 2010;122:1789-96.
  3. Breivik H. Treat the Whole Patient and Be Aware of Drug Interactions. Journal of Pain & Palliative Care Pharmacotherapy 2015;29:70-71.
  4. Laubie M, et al. Central sites and mechanisms of the hypotensive and bradycardic effects of the narcotic analgesic agent fentanyl. Naunyn Schmiedebergs Arch Pharmacol. 1977;296:255-61.
  5. Mitaka C, et al. Comparison of hemodynamic effects of morphine, butorphanol, buprenorphine and pentazocine on ICU patients. Bull Tokyo Med Dent Univ. 1985;32:31-9.
  6. Buckley NA, Dawson AH, et al. Br Med J. 2014;348:g1626.
  7. Boyer EW, Shannon M. N Engl J Med. 2005;352(11):1112-20.
  8. Jette N, Veregin T, Guberman A. Carbamazepine - induced hypertension. Neurology 2002;59:275-6.

Pain Treatment + Kidney

  1. Stueber T et al. The use of dipyrone in the ICU is associated with acute kidney injury: A retrospective cohort analysis. Eur J Ansthesiol. 2017.
  2. Sandler DP, Smith JC, Weinberg CR et al. Analgesic use and chronic renal disease. N Eng J Med 1989;320:1238.
  3. Filitz J, Griessinger N, Sittl R, et al. Effect of intermittent hemodialysis on buprenorphine and norbuprenorphine plasma concentration in chronic pain patients treated with transderma buprenorphine. Eur J Pain 2006; 10:743.
  4. Gibson TP.Pharmacokinetics, efficacy and safety of analgesia with a focus on tramadol HCL. Am J Med 1996;101:47S.
  5. Lintz W, Erlacin S, Frankus E,Uragg H. Biotransformation of tramadol in man and animal (Author's trans.). Arzeneimittelforschung 1981;31:1932.
  6. Barnes JN, Goodwin FJ. Dihydrocodeine narcosis in renal failure. Br Med J (Clin Res Ed) 1983;286:438.
  7. Guay DR, Awni WM, Findlay JW et al. Pharmacokinetics and pharmacodynamics of codeine in ESRD. Clin Pharmacol Ther 1988;43:63.
  8. Noels LM, Elseviers MM, de Broe ME. Impact of legislative measures on the sales of analgesics and the subsequent prevalence of analgesic nephropathy: A comparative study in France, Sweden and Belgium. Nephrol Dial Transplant 1995;10:167.
  9. Ibanez L, Morlans M, Vidal X et al. Case control study of regular analgesics and NSAID use and ESRD. Kidney Int 2005;67:2393.
  10. Bennett WM, Henrich WL, Stoff JS. The renal effects of NSAIDS: summary and recommendations. Am J Kid Dis 1996;28:S56.
  11. Wagner EH. NSAIDS and renal disease -Still unsettled. Ann Intern Med 1991;115:227.
  12. Schwartz A, Krause PH, Kunzendorf U, et al. The outcome of acute interstitial nephritis: risk factors for the transition from acute to chronic interstitial nephritis. Clin Nephrol 2000;54:179.
  13. Perazella MA, Eras J. Are selective COX-2 inhibitors nephrotoxic? Am J Kid Dis. 2000;35(5).937.
  14. Gurwitz JH, Avorn J, Ross-Degnan D, et al. NSAIDS associated azotemia in the very old. JAMA 1990,264(4):471-5.
  15. Koehntop DE, Rodman JH. Fentanyl pharmacokineics in paients undergoing renal transplantation. Pharmacotherapy 1997;17:746.
  16. Bower S. Plasma protein binding of fentanyl: the efect of hyperlipoproteinemia and chronic renal failure. J Pharm Pharmacol 1982;34:102.
  17. Kreek MJ, Schecter AJ, Gutjahr CL, Hecht M. Methadone use in paients with chronic renal disease. Drug Alcohol depend 1980;5:197.
  18. Wolff J, Bigler D, Christensen CB, et al. Influence of renal function on the eliminaion of morphine and morphine glucuronides. Eur J Clin Pharmacol 1988;34:353.
  19. Foral PA, Ineck JR, Nystrom KK. Oxycodone accumulation in a hemodialysis paient. South Med J. 2007.
  20. Kirvela M, Lindgren L, Seppala T, Olkkola KT. The pharmacokineics of oxycodone in uremic paients undergoing renal transplantaion. J Clin Anesth 1996;8:13.
  21. Mclaughlin JK, Lipworth L, Chow WH, Blot WJ. Analgesic use and chronic renal failure: a criical review of the epidemiologic literature: Kidney Internaional 1998;54:679.
  22. Pilowsky I, Hallet EC, Basset DL, Thomas PG, Penhall RK. A controlled study of amitriptyline in the treatment of chronic pain. Pain. 1982; 14(2):169.
  23. Aiyer R, Barkin RL and Bhaia A et al. Treatment of neuropathic pain with venlafaxine: A systemaic review. Pain Med 2017; 18(10):1999.
  24. Randiniis EJ, Posvar EL, Alvey CW, Sedman AJ, Cook JA and Bockbrader HN et al. Pharmacokinetics of pregabalin in subjects with various degrees of renal function. J Clin Pharmacol. 2003; 43(3):277.
  25. Tramadol Drug Informaion.
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  27. Renoux C et al. SNRI and the risk of AKI: A cohort study of eight administraive databases And Meta-analysis. Clin JASN 2015.
  28. Venlafaxine: more dangerous than most "selective" serotonergic anidepressants Prescrire Int. 2016.

Pain Treatment + Diabetes

  1. FDA approved drugs; Feb; 2017. Drugs. Com, Clinical Pharmacology; 2017.
  2. PLOS One; 2015.
  3. Drugs.com; 2017.
  4. JAMA Pediatrics; Am J Dis Child.1966;112(6).
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  6. FDA approved drugs; Rxlist; John P. Cunha, 2016
  7. Oman Med J, 2010; Joslin Diabetes Center; 2017.
  8. Pamela Natalia Bellucci et al. Potential Effects of Nonsteroidal Anti-Inflamatory Drugs in the prevention and Treatment of type 2 Diabetes mellitus ; Journal of Pharmacy Practice 2017, Vol.30(5):549-556.
  9. J Li et al. Non- steroidal anti - inflammatory drugs increase insulin release from beta cells by inhibiting ATP - sensitive potassium channels, Br J of Pharmacology (2007)151:483-493.
  10. Br J Clin Pharmacol; 1981. Diab Med. 2015.
  11. Maahs DM et al. Effect of paracetamol on CGM Glucose in an Outpatient Setting. Diabetes Care: [2 pages], 12 Aug 2015.
  12. Simpson et al. Diabetes care 39(9):2016.
  13. Diabetes News Journal; Jan 2015; Haggstrom 2014; WikiJournal of Medicine; J Fam Pract. 2012 November; 61(11).
  14. medicalook.com. J Fam Prac. 2012 Nov;6(11)
  15. FDA approved drugs; 2017; J Fam Pract. 2012 November: 6(11).
  16. Roopan S, Larsen ER et al. Use of Antidepressants in patients with depression and comorbid diabetes mellitus: a systemic review; Acta Neuropsychiatrica 2017, DOI: 10.1017/ neu. 2016.54.
  17. Hardy et al. Does treatment with Duloxetine for neuropathic pain impact glicemic control?; Diabetes Care, Jan 2007, Vol.30, Issue1; 21-26.
  18. Boyle J et al. Randomized, placebo-controlled comparison of Amitriptyline, Duloxetine, and Pregabalin in patients with chronic diabetic peripheral neuropathic pain. Diabetes Care 2012 Dec;35(12):2451-8. Epub 2012, Sep 18.
  19. Joep H. G. Scholl, Rike van Eekeren and Eugene P. van Puijenbroek et al. Six cases of (severe) hypoglycaemia associated with gabapentin use in both diabeic and non-diabeic paients. BJCP, 2015 May: Vol 79(5); 870-871.
  20. Avanish Jha, Kundavaram Paul Prabhakar Abhilash, Rini Bandhyopadhyay, and Peter John Victor et al. Hypoglycemia - A rare complication of carbamazepine overdose. Indian J Pharmacol. 2014 Nov-Dec; 46(6): 651-652.
  21. VS Salice FV, Valenza MP, Pizzocri LV, Valenti GC, Chevallard MU, Umbrello SG, Gatti SF, Fargion GI, Iapichno and LG Gattinoni. Benzodiazepines induce hyperglycemia in rats by affecting periphera disposal of glucose. Crit Care. 2013; 17(Suppl 2): 385.
  22. Takeda; PI; Medicines.ie. J Fam Pract .2012.Nov;6 (11).

Pain Treatment + Coronary & CHF

  1. Schmitz et al., Dipyrone (metamizole) markedly interferes with platelet inhibition by aspirin in patients with acute and chronic pain: A case-control study. (htps://insights-ovid-com.beilinson-ez.medlcp.tau.ac.il/pubmed? pmid=28030443)
  2. Polzin et al., Prevention of dipyrone (metamizole) induced inhibition of aspirin aniplatelet efects. (htps://insights-ovid-com.beilinson-ez.medlcp.tau.ac.il/pubmed? pmid=25789542&isFromRelatedArticle=Y)
  3. Fanelli et al, Ther Adv Drug Saf 2017, Vol. 8(6) 173-182 (htps://www-ncbi-nlm-nih-gov.beilinson-ez.medlcp.tau.ac.il/pmc/ articles/PMC5455842/pdf/10.1177_2042098617690485.pdf)
  4. BMJ 2016 (htp://www.bmj.com.beilinson-ez.medlcp.tau.ac.il/content/354/ bmj.i4857.long)
  5. https://www-ncbi-nlm-nih-gov.beilinson-ez.medlcp.tau.ac.il/pubmed/21516735.
  6. Joseph P et al. DOI: 10.111/j.1533-2500.2008.00204.x; Opioids and the management of chronic severe pain in the elderly.
  7. http://onlinelibrary.wiley.com.beilinson-ez.medlcp.tau.ac.il/doi/10.1111/j.1533-2500.2008.00204.x/epdf
  8. HYPERLINK "https://www-ncbi-nlm-nih-gov.beilinson-ez.medlcp.tau. ac.il/pubmed/28616956" \o "The Cochrane database of systematic reviews." Cochrane Database Syst Rev. 2017 Jun 15;6:CD003726. DOI: 10.1002/14651858.CD003726.pub4.
  9. Tramadol for neuropathic pain in adults.
  10. htp://onlinelibrary.wiley.com/doi/10.1002/phar.1646/bstract;jsessionid=600D3406268896A1F9A7F3C76EEC3F1A.f04t03.
  11. htp://www.eurekaselect.com/120174/aricle.
  12. DOI: 10.1016/j.pcad.2015.11.003. Epub 2015 Nov 10.
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  14. DOI: 10.1002/pds.2186.
  15. DOI: 10.1016/j.clinthera.2013.10.11.
  16. DOI: 10.3904/kjim.2016.282. (htps://doi-org.beilinson-ez.medlcp.tau.ac.il/10.1016/j. atherosclerosis.2014.05.918)

Pain Treatment + PUD

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  2. Am J Gastroenterol 2009;104:728-38.
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  14. PLoS Medicine. 2017;14(8):e1002369. doi:10.1371/journal.pmed.1002369.
  15. J Pain Res. 2017 Nov 1;10:2547-2563.
  16. Expert Opinion on Orphan Drugs (2015) 14(11):1703-1724.
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  19. Am J Gastroenterol 2011; 106:835-842.
  20. PHYSICIAN'S LEAFLET TRAMADEX OD 100 / 200 /300 - Prolonged Released Tablets.
  21. Medicines and Healthcare Products Regulatory Agency.
  22. United European Gastroenterology Journal 2017, Vol. 5(4) 588-600.
  23. US Drug Enforcement Administration Automation of Reports and Consolidated Orders System (ARCOS); (www.deadiversion.usdoj.gov/ arcos/retail_drug_summary/index.html)

Pain Treatment + Cirrhosis

  1. Kotb HI, el-Kabsh MY, Emara SE, Fouad EA. Pharmacokinetics of controlled release morphine (MST) in paients with liver cirrhosis. Br J Anaesth. 1997;79(6):804-806.
  2. Mazoit JX, Sandouk P, Zetlaoui P, Scherrmann JM. Pharmacokinetics of unchanged morphine in normal and cirrhoic subjects. Anesth Analg. 1987;66(4):293-298.
  3. Bosilkovska M, Walder B, Besson M, Daali Y, Desmeules J. Analgesics in paients with hepaic impairment: pharmacology and clinical implicaions. Drugs. 2012;72(12):1645-1669.
  4. Tegeder I, Lotsch J, Geisslinger G. Pharmacokineics of opioids in liver disease. Clin Pharmacokinet. 1999;37(1):17-40.
  5. Hasselstrom J, Eriksson2 S, Persson ' A, Rane3 A, Svensson J 0, Sawe J. The metabolism and bioavailability of morphine in paients with severe liver cirrhosis. Br J clin Pharmac. 1990;29:289-297.
  6. Malhotra, PhD BK, Schoenhard, PhD GL, de Kater, PhD AW, Friedmann, PhD, MD N. The pharmacokineics of oxycodone and its metabolites following single oral doses of Remoxy, an abuse-deterrent formulation of extended-release oxycodone, in patients with hepaic or renal impairment. J Opioid Manag. 2015;11(2):157-169.
  7. Tallgren M, Olkkola KT, Seppala T, Hockerstedt K, Lindgren L. Pharmacokinetics and ventilatory effects of oxycodone before and after liver transplantation. Clin Pharmaco Ther. 1997;61(6):655-661.
  8. Chandok N, Wat KDS. Pain management in the cirrhoic paient: the clinical challenge. Mayo Clin Proc. 2010;85(5):451-458.
  9. Lee CR, McTavish D, Sorkin EM. Tramadol. A preliminary review of its pharmacodynamic and pharmacokineic properies, and therapeuic potenial in acute and chronic pain states. Drugs. 1993;46(2):313-340.
  10. Frye R, Zgheib N, Matzke G, et al. Liver disease selecively modulates cytochrome P450-mediated metabolism. Clin Pharmacol Ther. 2006;80(3):235-245.
  11. Claria J, Kent JD, Lopez-Parra M, et al. Effects of celecoxib and naproxen on renal funcion in nonazotemic paients with cirrhosis and ascites. Hepatology. 2005;41(3):579-587.
  12. Lill JS, O'Sullivan T, Bauer LA, et al. Pharmacokineics of diclofenac sodium in chronic acive hepaiis and alcoholic cirrhosis. J Clin Pharmacol. 2000;40(3):250-257.
  13. Juhl RP, Van Thiel DH, Ditert LW, Albert KS, Smith RB. Ibuprofen and sulindac kineics in alcoholic liver disease. Clin Pharmacol Ther. 1983;34(1):104-109.
  14. Ackerman Z, Cominelli F, Reynolds TB. Efect of misoprostol on ibuprofen-induced renal dysfuncion in paients with decompensated cirrhosis: results of a double-blind placebo-controlled parallel group study. Am J Gastroenterol. 2002;97(8):2033-2039.
  15. Lai G, Daskalopoulos G, Kronborg I, Hsueh W, Genilini P, Zipser RD. Efects of sulindac and ibuprofen in paients with cirrhosis and ascites. An explanaion for the renal-sparing efect of sulindac. Gastroenterology. 1986;90(1):182-187.
  16. Brater DC, Lasseter KC. Profile of etodolac: Pharmacokinetic evaluation in specia populaions. Clin Rheumatol. 1989;8(S1):25-35.
  17. Davies NM, McLachlan AJ, Day RO, Williams KM. Clinical pharmacokineics and pharmacodynamics of celecoxib: a selecive cyclo-oxygenase-2 inhibitor. Clin Pharmacokinet. 2000;38(3):225-242.
  18. Agrawal NGB, Mathews CZ, Mazenko RS, et al. Pharmacokineics of Etoricoxib in Paients with Renal Impairment. J Clin Pharmacol. 2004;44(1):48-58.
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